Victor Geller

I am a researcher at the intersection of systems biology, immunology, and clinical translation, focusing on systemic inflammation, not merely as a pathological outcome but as a central regulatory force in human physiology.

My research is guided by a simple but powerful question:

What does it indeed mean for our organism to be in balance?

This question has guided me toward a profoundly integrative and transdisciplinary approach. I don't see our bodies as a collection of isolated organs or static signaling pathways but as highly responsive, nonlinear networks. Within these nonlinear dynamics, a common thread begins to surface, chronic, low-grade inflammation acting as a subtle yet persistent regulator across systems. Examining physiology through nonlinear network dynamics uncovers a consistent theme: chronic, low-grade inflammation, a silent yet powerful force influencing various physiological outcomes, when analyzing data from psychiatry, dermatology, dentistry, or metabolic science.

Systemic inflammation functions as a biological language, a signaling process across organs and systems. From neuroinflammation related to mental health to low-grade immune activation seen in metabolic disorders, its influence is extensive yet often overlooked. By reframing inflammation as a regulatory phenomenon, I aim to reveal the common principles that link diverse clinical manifestations to a shared underlying logic. This acknowledgment forms the foundation of my work: to examine inflammation not as a symptom but as a central organizing process within human biology.

To investigate this logic, I employ systemic thinking: a method for understanding the body as a network of dynamic, interdependent processes, where health is defined not by static normalcy but by dynamic balance. This perspective shifts the focus from isolated variables to patterns of interaction, revealing how minor disruptions can cascade into systemic shifts. It also facilitates cross-disciplinary integration, enabling insights from one field to inform another in unexpected yet highly significant ways.

Biological systems are inherently self-regulating. My work in homeostatic modeling aims to describe how the body maintains internal stability through feedback, adaptation, and threshold modulation. Within this framework, I explore immunomodulation not merely as immune suppression or stimulation but as precision-guided recalibration-facilitating the immune system's return to functional balance with minimal interference. This philosophy respects the intelligence of biological systems and seeks to engage with their logic rather than override it.

Rooted in this philosophy, I embrace a minimalist scientific approach, prioritizing clarity, restraint, and precision over excess. I design research and interventions that are elegant, efficient, and aligned with the organism's native logic. I focus on doing less but doing it better, avoiding unnecessary interventions, and creating strategies that enhance the body's capacity for self-correction, resolution, and resilience. Whether in experimental design or clinical translation, my goal is to minimize noise, amplify signals, and allow biology to perform its functions effectively.

These principles converge in one of my key research areas: the development of multiparametric composite indices to measure immune dynamics and systemic inflammation. By integrating multiple biomarkers into unified, dynamic metrics, these indices capture the complexity and nuance of immune behavior over time, offering a high-resolution functional portrait of systemic immune activity. Designed for research and clinical contexts, they bridge the gap between research and practice, enabling more informed diagnostics, monitoring, and translational insight.

I collaborate across disciplines and institutions, and my work often lies between research and real-world application, where scientific insight turns into actionable strategy. If you're a fellow researcher, clinician, student, or simply curious about how inflammation influences the human condition, I invite you to explore this work with me.